OTC anti-aging products represent a billion dollar industry: wrinkle creams have been marketed to the American public since the early 19th century, and Americans spent more than $2 billion on these products in 2000 alone. While a limited body of evidence exists to prove the efficacy of many of these products, their popularity continues to increase.
A study by the Aesthetic Surgery Journal, the official peer-reviewed journal of the American Society for Aesthetic Plastic Surgery (ASAPS), released in July 2007 reveal that a limited amount of clinical research exists to prove the effectiveness of many over-the-counter (OTC) anti-aging products.
This is what the study says about antioxidants, such as Omega 5 oil:
Plant polyphenols are responsible for the intrinsic antioxidant properties found in botanicals. Polyphenols can be divided into several classes of chemicals: anthocyanins, bioflavonoids, proanthocyanidins, catechins, hydroxycinnamic acids, and hydroxybenzoic acids.57 Various plants used in anti-aging creams contain these compounds. Anthocyanins are found in red wine and berries; bioflavonoids are found in citrus fruits, soybeans, red wine, Ginkgo biloba, and many other vegetables; proanthocyanidins are found in coca, red wine, grape seed extract, green tea, and black tea; catechins are found in tea, chocolate, apples, pears, grapes, and red wine; hydroxycinnamic acids are found in coffee and red wine; and hydroxybenzoic acids are found in fruits, nuts, tea, and red wine.57
Bioflavonoids are antioxidant, anticancer, and antiinflammatory.58, 59, 60 Bioflavonoids also inhibit UV-induced matrix metalloproteinases, which cause connective tissue damage to the skin.2, 61 Anthocyanins, a group of flavonoids present in many common vegetables, have been shown to decrease UVB-induced DNA fragmentation and reactive oxygen species in human keratinocytes, thereby decreasing cancer formation.62, 63 Proanthocyanidins are believed to inhibit production of free radicals and inflammatory pathways, such as histamine, serine protease, prostaglandins, and leukotrienes.64 There have been many in-vitro cell culture and animal experiments investigating the photoprotective potential of commonly used botanicals, but relatively few randomized placebo-controlled human clinical studies have been conducted. Several representative findings are summarized in the Table. Given the limited data, it is not yet possible to formulate any conclusions on the efficacy of botanicals.
Full article can be found at the Journal and commentary at: http://www.associatedcontent.com/article/345906/antiaging_creams_not_effective_study.html.
The study consisted of a review of existing research on ingredients commonly found in OTC anti-aging creams. Key compounds under review included vitamins, antioxidants, alpha-hydroxyl acids, moisturizers, pentapeptides and botanicals. Of these, Vitamin C, alpha-hydroxyl acids and pentapeptides were shown to be the most extensively researched with proven anti-aging benefits.
Vitamin A, or retinols have shown great promise, however their effects have only been proven in prescription-strength formulations; OTC benefits have not been determined. Minimal studies have been performed on Vitamin B, though what evidence does exist is promising. Moisturizers have not been extensively researched, but have been shown to improve the hydration and appearance of skin.
Botanicals such as grape seed extract, pomegranate seed oil [ has not been tested in this study] soy compounds, green tea and Gingko biloba are relatively new in the market and have gained great popularity in recent years, but their healing qualities have yet to be proven through randomized, placebo-controlled human trials. Many cell culture and animal experiments have been conducted to investigate the efficacy of these botanical compounds, however, indicating the potential for many beneficial effects such as increased collagen expression, improved antioxidant activity, accelerated healing and enhanced hydration. With regard to Omega 5 oil -- Please see this article: http://newsblaze.com/story/2006081612230000001.sp/topstory.html and http://www.fromnaturewithlove.com/product.asp?product_id=oilpomegranate
The study underscores the need for much greater study of, and public education on, the effectiveness of OTC anti-aging products although there are a number of beneficial OTC remedies in existence, for many patients, prescription-strength or surgical procedures may be necessary to achieve desired results. Consumers need to be realistic about the outcomes they can expect from OTC anti-aging creams, at least until solid clinical evidence of their efficacy exists.
To the best of our knowledge, Omega 5 oil has been tested to indicate very promising anti – aging results. See Dr. Mark Tallon , PHD, at his article: Cosmecuticals: the new hope for ageign skin at: http://www.ffnmag.com/ASP/articleDisplay.asp?strArticleId=993&strSite=FFNSite
A study by the Aesthetic Surgery Journal, the official peer-reviewed journal of the American Society for Aesthetic Plastic Surgery (ASAPS), released in July 2007 reveal that a limited amount of clinical research exists to prove the effectiveness of many over-the-counter (OTC) anti-aging products.
This is what the study says about antioxidants, such as Omega 5 oil:
Plant polyphenols are responsible for the intrinsic antioxidant properties found in botanicals. Polyphenols can be divided into several classes of chemicals: anthocyanins, bioflavonoids, proanthocyanidins, catechins, hydroxycinnamic acids, and hydroxybenzoic acids.57 Various plants used in anti-aging creams contain these compounds. Anthocyanins are found in red wine and berries; bioflavonoids are found in citrus fruits, soybeans, red wine, Ginkgo biloba, and many other vegetables; proanthocyanidins are found in coca, red wine, grape seed extract, green tea, and black tea; catechins are found in tea, chocolate, apples, pears, grapes, and red wine; hydroxycinnamic acids are found in coffee and red wine; and hydroxybenzoic acids are found in fruits, nuts, tea, and red wine.57
Bioflavonoids are antioxidant, anticancer, and antiinflammatory.58, 59, 60 Bioflavonoids also inhibit UV-induced matrix metalloproteinases, which cause connective tissue damage to the skin.2, 61 Anthocyanins, a group of flavonoids present in many common vegetables, have been shown to decrease UVB-induced DNA fragmentation and reactive oxygen species in human keratinocytes, thereby decreasing cancer formation.62, 63 Proanthocyanidins are believed to inhibit production of free radicals and inflammatory pathways, such as histamine, serine protease, prostaglandins, and leukotrienes.64 There have been many in-vitro cell culture and animal experiments investigating the photoprotective potential of commonly used botanicals, but relatively few randomized placebo-controlled human clinical studies have been conducted. Several representative findings are summarized in the Table. Given the limited data, it is not yet possible to formulate any conclusions on the efficacy of botanicals.
Full article can be found at the Journal and commentary at: http://www.associatedcontent.com/article/345906/antiaging_creams_not_effective_study.html.
The study consisted of a review of existing research on ingredients commonly found in OTC anti-aging creams. Key compounds under review included vitamins, antioxidants, alpha-hydroxyl acids, moisturizers, pentapeptides and botanicals. Of these, Vitamin C, alpha-hydroxyl acids and pentapeptides were shown to be the most extensively researched with proven anti-aging benefits.
Vitamin A, or retinols have shown great promise, however their effects have only been proven in prescription-strength formulations; OTC benefits have not been determined. Minimal studies have been performed on Vitamin B, though what evidence does exist is promising. Moisturizers have not been extensively researched, but have been shown to improve the hydration and appearance of skin.
Botanicals such as grape seed extract, pomegranate seed oil [ has not been tested in this study] soy compounds, green tea and Gingko biloba are relatively new in the market and have gained great popularity in recent years, but their healing qualities have yet to be proven through randomized, placebo-controlled human trials. Many cell culture and animal experiments have been conducted to investigate the efficacy of these botanical compounds, however, indicating the potential for many beneficial effects such as increased collagen expression, improved antioxidant activity, accelerated healing and enhanced hydration. With regard to Omega 5 oil -- Please see this article: http://newsblaze.com/story/2006081612230000001.sp/topstory.html and http://www.fromnaturewithlove.com/product.asp?product_id=oilpomegranate
The study underscores the need for much greater study of, and public education on, the effectiveness of OTC anti-aging products although there are a number of beneficial OTC remedies in existence, for many patients, prescription-strength or surgical procedures may be necessary to achieve desired results. Consumers need to be realistic about the outcomes they can expect from OTC anti-aging creams, at least until solid clinical evidence of their efficacy exists.
To the best of our knowledge, Omega 5 oil has been tested to indicate very promising anti – aging results. See Dr. Mark Tallon , PHD, at his article: Cosmecuticals: the new hope for ageign skin at: http://www.ffnmag.com/ASP/articleDisplay.asp?strArticleId=993&strSite=FFNSite
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