Monday, April 7, 2008

Milk or Pomegranates Omega 5 oil -- the prostate dilema

In labs, Omega 5 oil has shown the potantial
of anti tumor activity against prostate cancer
So, should I drink less milk and use Omega 5 oil soft gel caps instead?
Natasha demonstrates an unusual and provocative benefit of milk
Pehaps she should have used POMEGA5 oil


A provocative study from Harvard Medical School shows that men who eat diary products regularly have a 30 percent greater chance of suffering prostate cancer than those who eat less than half a serving per day.How can this be?

Isn't milk a health food? Many of you will be shocked by these findings, but this study is the largest done yet, it is done by arguably the most respected epidemiology teams in the world and there is a physiologic explanation for the results. Milk is loaded with calcium and taking large amounts of calcium lowers blood levels of the body's form of vitamin D called 1,24 dihydroxyvitamin D that prevents cancers (2). Of course, milk is usually fortified with vitamin D, but there is so much more calcium than vitamin D in milk that the extra calcium drains vitamin D from the body.

This study shows that men who take in more than six glasses of vitamin D fortified milk per week have lower levels of vitamin D than those who take in fewer than two glasses. This tells you that you shouldn't believe everything that you hear, even if it comes from scientific studies. These studies imply that you don't need to drink milk and that taking calcium supplements may harm you. Lack of vitamin D is usually caused by lack of sunlight as very few people get the vitamin D that they need from food. Vitamin D deficiency is common in winter, particularly in people who live in the northern parts of the globe and people with dark skin.

1) Results of the Physicians Study presented at the American Association for Cancer Research in San Francisco April 4, 2000. 2) AM Barreto, GG Schwartz, R Woodruff, SC Cramer. 5-hydroxyvitamin D-3, the prohormone of 1,25-dihydroxyvitamin D-3, inhibits the proliferation of primary prostatic epithelial cells.Cancer Epidemiology Biomarkers & Prevention, 2000, Vol 9, Iss 3, pp 265-270. these findings support a potential role for vitamin D in the
John's family insists that he uses Omega 5 oil

Journal of Medicinal Food

Pomegranate Extracts Potently Suppress Proliferation, Xenograft Growth, and Invasion of Human Prostate Cancer Cells

To cite this paper:Martin Albrecht, Wenguo Jiang, James Kumi-Diaka, Ephraim P. Lansky, Lyndon M. Gommersall, Amit Patel, Robert E. Mansel, Ishak Neeman, Albert A. Geldof, Moray J. Campbell. Journal of Medicinal Food. September 1, 2004, 7(3): 274-283. doi:10.1089/jmf.2004.7.274.

Martin Albrecht Institute of Anatomy and Cell Biology, Philipps University, Marburg, GermanyWenguo Jiang University Department of Surgery, University of Wales College of Medicine, Cardiff James Kumi-Diaka Division of Science, College of Liberal Arts, Florida Atlantic University, Davie, Florida, U.S.A. Ephraim P. Lansky Rimonest Ltd. Lyndon M. Gommersall Division of Medical Sciences, University of Birmingham Medical School, Birmingham, United Kingdom Amit Patel Division of Medical Sciences, University of Birmingham Medical School, Birmingham, United Kingdom Robert E. Mansel University Department of Surgery, University of Wales College of Medicine, Cardiff Ishak Neeman Rimonest Ltd. Department of Food Engineering and Biotechnology, Technion-Israel Institute of Technology, Haifa, Israel Albert A. Geldof Departments of Urology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands Moray J. Campbell Division of Medical Sciences, University of Birmingham Medical School, Birmingham, United Kingdom

We completed a multicenter study of the effects of pomegranate cold-pressed (Oil) or supercritical CO2-extracted (S) seed oil, fermented juice polyphenols (W), and pericarp polyphenols (P) on human prostate cancer cell xenograft growth in vivo, and/or proliferation, cell cycle distribution, apoptosis, gene expression, and invasion across Matrigel, in vitro. Oil, W, and P each acutely inhibited in vitro proliferation of LNCaP, PC-3, and DU 145 human cancer cell lines. The dose of P required to inhibit cell proliferation of the prostate cancer cell line LNCaP by 50% (ED50) was 70 mg/mL, whereas normal prostate epithelial cells (hPrEC) were significantly less affected (ED50 5 250 mg/mL).

These effects were mediated by changes in both cell cycle distribution and induction of apoptosis. For example, the androgen-independent cell line DU 145 showed a significant increase from 11% to 22% in G2/M cells (P , .05) by treatment with Oil (35 µg/mL) with a modest induction of apoptosis. In other cell lines/treatments, the apoptotic response predominated, for example, in PC-3 cells treated with P, at least partially through a caspase 3-mediated pathway. These cellular effects coincided with rapid changes in mRNA levels of gene targets. Thus, 4-hour treatment of DU 145 cells with Oil (35 µg/mL) resulted in significant 2.3 ± 0.001-fold (mean ± SEM) up-regulation of the cyclin-dependent kinase inhibitor p21(waf1/cip1) (P < .01) and 0.6 ± 0.14-fold down-regulation of c-myc (P < .05). In parallel, all agents potently suppressed PC-3 invasion through Matrigel, and furthermore P and S demonstrated potent inhibition of PC-3 xenograft growth in athymic mice.

Overall, this study demonstrates significant antitumor activity of pomegranate-derived materials against human prostate cancer.

Journal of Medicinal Food

Chemopreventive Effects of Pomegranate Seed Oil on Skin Tumor Development in CD1 Mice
To cite this paper:Justin J. Hora, Emily R. Maydew, Ephraim P. Lansky, Chandradhar Dwivedi. Journal of Medicinal Food. October 1, 2003, 6(3): 157-161. doi:10.1089/10966200360716553.Justin J. Hora Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, U.S.A Emily R. Maydew Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, U.S.A Ephraim P. LanskyRimonest Ltd., Horev Center, Haifa, Israel Chandradhar Dwivedi Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD, U.S.A

Pomegranate seed oil was investigated for possible skin cancer chemopreventive efficacy in mice.

In the main experiment, two groups consisting each of 30, 4-5-week-old, female CD1 mice were used. Both groups had skin cancer initiated with an initial topical exposure of 7,12-dimethylbenzanthracene and with biweekly promotion using 12-O-tetradecanoylphorbol 13-acetate (TPA). The experimental group was pretreated with 5% pomegranate seed oil prior to each TPA application.

Tumor incidence, the number of mice containing at least one tumor, was 100% and 93%, and multiplicity, the average number of tumors per mouse, was 20.8 and 16.3 per mouse after 20 weeks of promotion in the control and pomegranate seed oil-treated groups, respectively (P < .05).

In a second experiment, two groups each consisting of three CD1 mice were used to assess the effect of pomegranate seed oil on TPA-stimulated ornithine decarboxylase (ODC) activity, an important event in skin cancer promotion. Each group received a single topical application of TPA, with the experimental group receiving a topical treatment 1 h prior with 5% pomegranate seed oil. The mice were killed 5 h later, and ODC activity was assessed by radiometric method. The experimental group showed a 17% reduction in ODC activity. Pomegrante seed oil (5%) significantly decreased (P < .05) tumor incidence, multiplicity, and TPA-induced ODC activity.
Overall, the results highlight the potential of pomegranate seed oil as a safe and effective chemopreventive agent against skin cancer.
The POMEGA5 collection



Organic skin care
pomegranate seed oil

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